A Comprehensive Review of Leflunomide Analytical Analysis: Spectroscopic Technique, Chromatographic Condition, Detection Limits and Validation Parameters.

Authors

  • Sanket Gothi Author
  • Dr. Pragnesh Patani Author
  • Mr. Vijendra Rajan Author
  • Dr. Neha Tiwari Author

DOI:

https://doi.org/10.53555/AJBR.v28i2S.7544

Keywords:

Leflunomide, RP HPLC-UV, LC-MS/MS, UV-Visible Spectroscopy, UPLC

Abstract

Leflunomide is a medication that is used to treat the symptoms of rheumatoid arthritis. It is classified as a pyrimidine synthesis inhibitor (DMARD) type of therapy. Additionally, it improves physical functioning, lessen

joint damage, and slows the advancement of disease-related structural damage. The material published in different pharmaceutical publications has been thoroughly studied, and the instrumental analytical techniques created and employed for Leflunomide determination have also been examined. UV-Visible Spectroscopy, RP-HPLC-UV, LC-MS/MS, and UPLC are all included in this review. This article has also covered the use of these techniques for determining the amount of leflunomide in biological samples and pharmaceutical formulations.

Author Biographies

  • Sanket Gothi

    Department of Pharmaceutical Quality Assurance, Khyati College of Pharmacy, Palodia, Gujarat Technology University, Ahmedabad, Gujarat.

  • Dr. Pragnesh Patani

    Principal and Professor, Department of Pharmacology, Khyati College of Pharmacy, Palodia, Gujarat Technology University, Ahmedabad, Gujarat, India.

  • Mr. Vijendra Rajan

    Associate Professor, Department of Pharmaceutical Chemistry and Quality Assurance, Khyati College of Pharmacy, Palodia, Gujarat Technology University, Ahmedabad, Gujarat, India.

  • Dr. Neha Tiwari

    Professor, Department of Pharmaceutical Chemistry and Quality Assurance, Khyati College of Pharmacy, Palodia, Gujarat Technology University, Ahmedabad, Gujarat, India.

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Published

2025-02-24

Issue

Vol. 28 No. 2S (2025)

Section

Research Article

License

Copyright (c) 2025 Sanket Gothi, Dr. Pragnesh Patani, Mr. Vijendra Rajan, Dr. Neha Tiwari (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

A Comprehensive Review of Leflunomide Analytical Analysis: Spectroscopic Technique, Chromatographic Condition, Detection Limits and Validation Parameters. (2025). African Journal of Biomedical Research, 28(2S), 1912-1915. https://doi.org/10.53555/AJBR.v28i2S.7544

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