RP-UPLC Analytical Method Development For Simultaneous Estimation Ritodrine By Analytical Qbd (Aqbd)) Approach

Abstract

A simple, Accurate, precise method was developed for the estimation of the Ritodrine in bulk and pharmaceutical dosage form. Chromatogram was run through Hibar100 x 2.1 mm, 2m. Mobile phase containing 0.1N OPA: Acetonitrile taken in the ratio 55(%v/v) and 45 was pumped through column at a flow rate of 0.9 ml/min. Temperature was maintained at 30°C. Optimized wavelength selected was ACQUITY TUV ChA 220.0 nm. Retention time of Ritodrine was found to be 1.065 min. %RSD of the Ritodrine was found to be 1.5. % Recovery was obtained as 99.95% for Ritodrine. Regression equation of Ritodrine is y = 69931x + 4571.9. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.