Design And Evaluation Of In Situ Gels For Ophthalmic Drug Delivery For Fluroquinolone

Abstract

The aim of the present work was design and evaluation of in situ gelling system of Gatifloxacin Sesquihydrate. Gatifloxacin Sesquihydrate is an antibacterial agent which exhibits rapid precorneal elimination and poor ocular bioavailability, when given in the form of conventional ophthalmic solutions. To overcome this, an attempt has been made to formulate pH-triggered in situ gelling system of Gatifloxacin Sesquihydrate to provide sustained release of drug based on polymeric carriers that undergo sol-to-gel transition upon change in pH. The Gatifloxacin Sesquihydrate in situ gelling system formulated by using poly acrylic acid (Carbopol 940P) in combination with Hypermellose which acted as viscosity enhancing agent. The developed formulation was stable, non-irritant and provided sustained release over 8-hour period and it is a viable alternative to conventional eye drops.