Ajasrika Rasayana: An Integrative Review of Traditional Ayurvedic Principles and Modern Scientific Perspectives

Abstract

Background: Ayurveda, the traditional Indian system of medicine, emphasizes preventive health through Rasayana (rejuvenation) therapy. Ajasrika Rasayana, a subset of Rasayana, is defined by the daily consumption of specific nourishing foods for health maintenance and disease prevention, offering a sustainable model for lifelong well-being.

Objective: This integrative review aims to synthesize the classical Ayurvedic doctrine of Ajasrika Rasayana with modern scientific evidence to evaluate its principles, key components, and potential mechanistic underpinnings.

Methods: A systematic literature search was conducted using PubMed, Scopus, Google Scholar, and the AYUSH Research Portal. Classical Ayurvedic texts—Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya—were reviewed. Search terms included Ajasrika Rasayana, Rasayana, ghee, milk, honey, rejuvenation, Ojas, and Ayurveda. Studies were included if they discussed classical definitions, pharmacological properties, or biomedical research on the key components.

Results: Classical texts describe Ajasrika Rasayana as the perpetual (ajasram) use of wholesome foods like cow's ghee (Ghrita), milk (Ksheera), and honey (Madhu) to nourish bodily tissues (dhatus) and enhance Ojas (vitality). Ghrita is traditionally Medhya (intellect-promoting) and Ojovardhaka (immunity-enhancing), with modern science identifying its butyric acid (supporting gut health), conjugated linoleic acid (CLA), and antioxidant properties. Ksheera is Jivaniya (life-promoting), correlating with its high-quality protein, calcium, and immunomodulatory lactoferrin content. Madhu's Yogavahi (catalyst) and Ropana (healing) properties align with its scientifically proven antimicrobial, antioxidant, and wound-healing activities.

Conclusion: The traditional concept of Ajasrika Rasayana finds resonance in modern nutritional science. The core components are rich in bioactive compounds that support gut health, immunity, and reduce oxidative stress, providing a plausible scientific basis for their rejuvenative claims. This synergy positions Ajasrika Rasayana as a valuable, evidence-informed dietary strategy for preventive health within integrative medicine.