Formulation And Evaluation Of Donepezil Hydrochloride Microsphere For The Treatment Of Alzheimer

Abstract

Alzheimer’s disease (AD) is a progressive neurological disorder marked by severe cognitive decline and memory impairment, for which Donepezil Hydrochloride (Donepezil HCl) is a commonly used therapeutic agent. Donepezil HCl, an acetylcholinesterase inhibitor, offers symptomatic relief for AD, but its therapeutic efficacy is limited by its short half-life, necessitating frequent dosing which can affect patient adherence. This thesis investigates the formulation and evaluation of Donepezil HCl-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres using the oil-in-water (O/W) emulsion solvent evaporation method as a strategy to achieve controlled, extended release of the drug. The study began with the development of Donepezil HCl-loaded PLGA microspheres through a systematic optimization of the O/W emulsion solvent evaporation technique. Various experimental parameters were evaluated, including the concentration of PLGA, the drug-to-polymer ratio, and the conditions for emulsification and solvent evaporation. These parameters were meticulously adjusted to achieve high encapsulation efficiency, optimal particle size distribution, and a desirable release profile for Donepezil HCl.