Association of MTNR1B Gene Polymorphisms and Expression with Gestational Diabetes Mellitus (GDM) Incidence: A Case-Control Study

Abstract

Objective: This study aims to explore the relationship between MTNR1B gene expression and specific genetic polymorphisms, and their association with an increased incidence of Gestational Diabetes Mellitus (GDM).

Methods: A case-control study was conducted with 150 women diagnosed with GDM and 150 healthy controls. MTNR1B gene expression was quantified using quantitative PCR, and genetic polymorphisms were analyzed through SNP genotyping. Statistical evaluations were performed to determine the associations between MTNR1B variants and GDM incidence.

Results: The study found significant alterations in MTNR1B gene expression in GDM patients compared to healthy controls. Notably, the rs10830963 polymorphism in MTNR1B was significantly associated with a higher risk of GDM. Additionally, MTNR1B gene expression levels were found to correlate with the presence of this polymorphism.

Conclusions: The findings emphasize the crucial role of MTNR1B in the pathophysiology of GDM. Variations in MTNR1B and its altered expression levels could potentially serve as biomarkers for assessing GDM risk and provide insights into its molecular mechanisms.