In Vitro Anti-Clot Effects of Ginger Extract, Ginger-Derived Nanoparticles, and Alteplase on Human Blood

Abstract

The result of clot weight show significant difference between treatment groups, in alteplase show the least value of clot weight 0.09 ±0.02 mg In lower concentration between treatment groups and in high concentration 0.02 ±0.00 mg , while in Ginger derived Nanoparticles show 0.14 ±0.02 mg in lower concentration between treatment groups and in high concentration 0.03 ±0.00 mg, and ginger extract show highest clot weight with 0.19 ±0.05 mg in lower concentration between treatment groups and in high 0.14 ±0.0 mg and the positive control at zero time with 0.20 ±0.04 mg. Hemoglobin quantity show significant difference post 30 min. and post 45 min. increase in post 45 min. and show significant difference between the treatment groups, in alteplase show the highest value of Hemoglobin quantity 0.620 ±0.10 mg/dl post 45 min. and 0.220 ±0.03 mg/dl post 30 min., while in Ginger derived Nanoparticles show o.400 ±0.10 mg/dl post 45 min. and 0.280 ±0.04 mg/dl post 30 min, and ginger extract show less with 0.380 ±0.09 mg/dl post 45 min. and 0.280 ±0.06 mg/dl post 30 min. and the least positive control with 0.040 ±0.02 mg/dl post 45 min. and 0.620 ±0.10 mg/dl post 30 min. Fibrinogen quantity show significant difference post 30 min. and post 45 min. decrease in post 45 min. and show significant difference between the treatment groups, in alteplase show the least value of Fibrinogen quantity 16.70 ±1.43 mg/dl post 45 min. and 18.36 ±1.14 mg/dl post 30 min., while in Ginger derived Nanoparticles show 17.65 ±1.17 mg/dl post 45 min. and 19.60 ±1.16 mg/dl post 30 min, and ginger extract show less with 22.62 ±1.01 mg/dl post 45 min. and 23.07 ±0.92 mg/dl post 30 min. and the highest positive control with 25.74 ±0.26 mg/dl post 45 min. and 26.06 ±0.24 mg/dl post 30 min. Fibrin quantity show significant difference post 30 min. and post 45 min. increase in post 45 min. and show significant difference between the treatment groups, in alteplase show the highest value of Fibrin quantity 82.49 ±3.82 mg/dl post 45 min. and 74.81 ±7.53 mg/dl post 30 min., while in Ginger derived Nanoparticles show 70.45 ±5.81 mg/dl post 45 min. and 62.36 ±4.74 mg/dl post 30 min, and ginger extract show less with 25.45 ±3.16 mg/dl post 45 min. and 21.72 ±2.35 mg/dl post 30 min. and the least positive control with 5.14 ±0.80 mg/dl post 45 min. and 5.59 ±0.63 mg/dl post 30 min.