In Vitro Evaluation of Ginger Extract and Ginger-Derived Nano-lipids on Platelet Activation, Fibrinolysis, and Fibrin Formulation

Abstract

Platelet count show significant difference between plasma poor platelet and plasma rich platelet that increase in plasma rich platelet and show significant difference between the treatment groups, in alteplase show the highest value of platelet count 5.20 ±0.66, while in Ginger derived Nanoparticles show 2.40 ±0.74, and ginger extract show less with 3.00 ±0.63 and the least positive control with 2.20 ±0.37 in plasma poor platelet and in plasma rich platelet; Ginger derived Nanoparticles show 8.40 ±0.67 show the highest value while in alteplase of platelet count 8.20 ±0.86, and ginger extract show less with 5.20 ±0.37and the least positive control with 2.00 ±0.31.fibrinogen quantification shows nonsignificant difference between plasma poor platelet and plasma rich platelet and show significant difference between the treatment groups, the alteplase treatment group decrease more than Ginger derived Nanoparticles and ginger extract groups in fibrinogen quantity in alteplase show the least value of fibrinogen quantification 18.25 ±4.29, while in Ginger derived Nanoparticles show 34.17 ±3.39, and ginger extract show more with 40.08 ±3.58 and the highest positive control with 61.45 ±0.35 in plasma poor platelet and in plasma rich platelet; in alteplase show the least value of fibrinogen quantification 25.77 ±4.82, while in Ginger derived Nanoparticles show 47.98 ±4.32, and ginger extract show more with 53.19 ±2.92 and the highest positive control with 61.13 ±0.31.Fibrin quantification show nonsignificant difference between plasma poor platelet and plasma rich platelet, while in group of ginger extract show significant difference between plasma poor platelet and plasma rich platelet and show significant difference between the treatment groups, fibrin quantification shows nonsignificant increase in alteplase treatment group more than Ginger derived Nanoparticles and ginger extract groups in fibrin quantity, in alteplase show the highest value of Fibrin quantification 48.91 ±10.56, while in Ginger derived Nanoparticles show 41.54 ±7.20, and ginger extract show less with 40.08 ±3.58 and the least positive control with 2.84 ±0.26 in plasma poor platelet and in plasma rich platelet; alteplase of Fibrin quantification 41.71 ±9.80 show the highest value while in Ginger derived Nanoparticles show 36.44 ±7.73  and ginger extract show less with 8.59 ±2.81 and the least positive control with 2.24 ±0.53.These findings suggest that ginger and its derivatives may have therapeutic potential in preventing and treating thrombotic disorders. Human clinical trials are necessary to assess the therapeutic potential of ginger-based interventions in patients with thrombotic disorders.