Analytical Techniques For Determination Of Leflunomide And Its Combinations: A Review

Abstract

Leflunomide is a medication that is used to treat the symptoms of rheumatoid arthritis. It is classified as a pyrimidine synthesis inhibitor (DMARD) type of therapy. The autoimmune illness rheumatoid arthritis (RA) is a multifactorial condition with an unclear origin that predominantly affects the joints, however it can also cause extra-articular symptoms. As an immunosuppressive medication, cyclosporine A is used to stop organ rejection following organ transplantation. Several autoimmune disorders, including severe rheumatoid arthritis, have been treated with it extensively. The goal is to create a Leflunomide Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) technology that is quick, inexpensive, and requires less mobile phase composition. The introduction of poly (methylvinylether-co-maleic anhydride) nanoparticles in new pharmaceutical dosage forms allowed for the quick and accurate measurement of cyclosporine A using a straightforward and established high performance liquid chromatography approach. Leflunomide in plasma was determined using LC-MS, HPLC, etc.