Estimation of fibrinogen concentration in pregnant and non-pregnant Female dogs

Abstract

The fibrinogen concentration in blood may increase in females dogs due to fetal implantation inside uterine mucosa in period of first month of gestation it could be a marker for pregnancy diagnosis in such cases . The aim of  study was to determine whether fibrinogen can be used as a pregnancy marker in female dogs.  Thirteen female dogs were divided into three groups: first group were given PMSG & hCG hormones IM injection, second group were given o.5 μg/kg of Cabergoline orally, and third group were not given any treatment. The result show that Values of animal response percentage to estrus  in three different groups of study ( G1 (PMSG+HCG) , G2 (Cabergoline) and G3 (control) ) were 100% , 100%  and 33.33%  respectively . The mean values of blood fibrinogen concentration before pregnancy were (134.25±7.22, 157.80±10.56 and 158.66±27.83) in G1 , G2 and G3 respectively. While the mean values of fibrinogen during first month of pregnancy were (396.00±18.49 , 390.80±10.91 and 140.66±21.85) in G1 , G2 and G3 respectively . The results proved that there is a significant (P˂ 0.05) . The results proved that there is a significant (P˂ 0.05) increase in blood fibrinogen level during the first month of pregnancy in treated groups (G1 and G2) . Vertically the result indicate no significant differences between the three deferent groups.  It was concluded that fibrinogen concentration may be considered as a means of pregnancy detection in healthy female dogs if it exceeds a level of 187 mg/dl.