Osmotic Fragility in Stored Non-Detergent Washed Human Erythrocytes

Authors

  • J.I. Okwusidi Author

DOI:

https://doi.org/10.4314/

Keywords:

Osmotic fragility, Stored washed human erythrocytes, Mean corpuscular fragility

Abstract

Osmotic fragility (OF) of non-detergent washed erythrocytes was evaluated in Nigerian human male 
erythrocytes stored for 0h, 12h, 24h and 48h. Storage of these human erythrocytes for up to 24h did not significantly alter their 
membrane characteristics. Mean corpuscular fragility (MCF) diminished and correlated negatively (r = -0.9668) with storage 
time. Only the 48h storage-time MCF exhibited significant variance compared to 0h, 12h and 24h (p <0.001). These results 
support OF-test data as reliable indices of alteration of membrane characteristics of non-detergent washed human erythrocytes 
stored for up to 24h. Non-detergent washing enhances erythrocytes OF test viability and hence the time window for meaningful 
OF test especially in situations of large sample volume

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Published

2024-09-15

Issue

Vol. 14 No. 2 (2011): May Issue

Section

Original Article

License

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Osmotic Fragility in Stored Non-Detergent Washed Human Erythrocytes. (2024). African Journal of Biomedical Research, 14(2), 143-146. https://doi.org/10.4314/