Silent Disease of The Current Scenario – MASH (Metabolic Dysfunction Associated Steatohepatitis)

Abstract

Metabolic Dysfunction Associated Steato Hepatitis (MASH) is emerging as the top most liver disease in today’s scenario because of the discouraging dietary pattern & poor lifestyle behaviour . MASH is a fatty liver disease and difficult to diagnose because of the symptoms being silent. Obesity, type 2 diabetes, metabolic syndrome and high fat levels in the blood are the common risk factors. Fatigue, unexplained weight loss, general weakness and discomfort in the right hypochondria are the non specific symptoms of MASH. The worst Complication of MASH is  cirrhosis of the liver. Cirrhosis can lead onto liver failure & sometimes to liver cancer. Liver function tests, lipid profile, fasting & postprandial blood glucose estimation, abdominal ultrasound, Computed Tomography(CT) scan and Magnetic Resonance Elastography (MRE)   will enable to clinch the diagnosis of MASH. Body weight reduction, proper dietary and  lifestyle plan, regular exercise, Yoga and drinking coffee will chase the disease away from us. Controlling the blood sugar, quitting smoking and alcohol, regular treatment of health conditions of Hyperlipidaemia and hormonal disorders, vaccinations against Hepatitis A and B, Covid -19, Flu, Pneumococcal infections will undoubtedly enable our population to be free from  MASH and its deleterious effects. Resmetirom ,SNP-630, SNP-630-MS  and anti oxidants like Vitamin E, selenium, and betaine are therapeutic drugs used in MASH with promising results.Let the Mystery disease MASH become a Maya (Illusion) and a myth by the effective practice of the aforementioned conglomerated preventive measures.