A Review On Nasal In Situ Noval Drug Delivery System Of Phytoconstituent For Brain Targeting Disease

Abstract

Brain disorder include Alzheimer’s , epilepsy , stroke , traumatic brain injury , aphasia , brain tumors , multiple sclerosis , schizophrenia , Parkinson’s . Gives the limitations of conventional pharmacotherapy , including side effect and drug resistance , the use of medicinal plant as complimentary treatment is gaining attention . At different synaptic levels in the brain, memory—one of the most developed human functions—proclaims activity-dependent synaptic plasticity. Cognition is the process by which the brain processes information. It includes memory, language processing, mental processes, and intellect. Many groupings of substances in different combinations termed nootropics are used therapeutically to increase cognitive processes in terms of general intelligence, enhance learning capacities, good thinking, react faster, and boost memory. Medications used frequently to treat brain disorders that enhance cognition include antipsychotics, selective estrogen receptor modulators, acetylcholinesterase inhibitors, and NMDAR medications. Following scientific investigations, siddha and Ayurvedic medicinal herbs such as Withania somniferous  (Ashwagandha), Centella asiatica, Terminalia chebula, Bacopa monnieri,mentha piperita (peppermint ), and Shankhpushpi were used to improve memory and intellectual function in brain. This review explores the therapeutic potential of various plant species traditionally employes in managing brain disorders . Compared to intravenous injection, nasal delivery of medications has advantages. In addition to bypassing gastrointestinal tract breakdown and liver first-pass metabolism, drugs can be quickly absorbed through the nasal mucosa, leading to a quick commencement of action. Drugs may enter the central nervous system (CNS) through the olfactory receptor cells, which have direct contact with the environment and the CNS.