Role of Serum Vitamin D3 and Immunoglobulin E in Allergic Rhinitis: Pilot Study
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Keywords

allergic rhinitis
vitamin d deficiency
serum immunoglobulin E

Abstract

Background: Allergic rhinitis (AR) is one of the commonest conditions with a significant impact on the quality of life. It is an inflammatory disease if nasal membrane, is characterized by symptoms such as sneezing, rhinorrhoea, nasal congestion and nasal itching.

AIM: The objective of the study was to estimate and compare serum Vitamin D3 and Immunoglobulin E in patients of allergic rhinitis and healthy controls.

Materials and Methods; The present  Pilot study was conducted in the Departments of Biochemistry and the Department of ENT, SGT Medical College, Hospital & Research Institute, Gurugram, Delhi-NCR, India. A written and informed consent was taken after explaining the purpose and details of the study to all the subjects of both the groups.  A total of 22 individuals with clinically confirmed allergic rhinitis, aged between 18 and 55 years, were seen in the ENT outpatient department at SGT Hospital. A total of twenty two  healthy volunteers, matched in terms of age and gender, was selected from the general public to serve as controls at SGT hospital. The measurement of Serum Vitamin D was conducted using a Competitive ELISA kit-based approach, whereas the measurement of and serum IgE was conducted using a Sandwich ELISA kit-based method. 

Results: It was observed that patients in the AR group had an average blood vitamin D level The present study showed decrease level of serum vitamin D in patients with allergic rhinitis as compared to that of healthy controls.   On comparing the mean values using the t- test the mean value of serum vitamin D in allergic rhinitis patients was found to be 16:31±5.6 which was significantly decrease as compared to that of controls which was found to be 56.31±35.58(p< 0.05.   On comparing the mean values using the t- test the mean value of serum Immunoglobulin E in allergic rhinitis patients was found to be 243±51.96 which was significantly increase as compared to that of controls which was found to be 62.59±86.08 (p< 0.05).

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