Constitutional Treatment of Major Depressive Disorder with Natrum Muriaticum in Fifty-Millesimal Potencies: A Clinical Case Study

Abstract

Major depressive disorder (MDD) is a prevalent psychiatric condition characterized by persistent sadness, loss of interest, and functional impairment. This report describes a 25-year-old woman with MDD, no history of bereavement, and intolerance to conventional antidepressants. Individualized homoeopathic treatment with Natrum muriaticum in fifty-millesimal potencies was selected after detailed repertorization using the Synthesis Repertory. Six follow-ups at approximately 15-day intervals, the patient exhibited phases of symptom aggravation and improvement before sustained remission. Hamilton Depression Rating Scale (HDRS₁₇) scores improved from 24 to 5. This case highlights the dynamic response pattern possible with LM potencies and the broader mental–emotional applicability of Natrum muriaticum.