In Silico Docking Studies Of Phyto- Constituents Detected In Nyctanthes Arbor Tristis Flowers Methanolic Extract For Anti Tubercular Activity.

Authors

  • Rasajna Guttala Author
  • Shaik Munvar Author
  • Devarapalli Pradeep Author
  • Chaitanya Lahari Meka Author
  • Pamu Divya Sarayu Author
  • Dr Jami Durga Ganesh Author

DOI:

https://doi.org/10.53555/AJBR.v27i4S.8790

Keywords:

GCMS, MABA, Nyctanthes arbour tristis, PASSonline, AUTODOCK.

Abstract

BACKGROUND: According to India TB report India faced its highest increase in TB cases with notified 26.07 lakhs, Treatment of TB is being difficult due to increased drug resistance so new anti-tubercular drugs are need of the hour. Medicinal Plants offered us potential therapeutic agents where modern analytical techniques like GCMS and Molecular Docking can help us to identify the compounds responsible for the therapeutic activity,

AIM:  The aim of our present study is to examine the anti-tubercular potential of phyto-constituents found in the Nyctanthesarbor-tristis flowers methanolic extract.

METHODS AND MATERIALS: The phyto constituents were analysed by GCMS and then potential compounds were estimated using SWISS ADME and PASSOnline server for estimated biological activity prediction and then Molecular docking was performed using AutoDock and the extract was undergone MABA screening.

RESULTS: The findings showed that several phytochemicals like had high binding affinity, suggesting that they interacted strongly with the Mtb target proteins' active regions. The Minimum Inhibitory Concentration of NME is observed at 12.5μg/ml.

Author Biographies

  • Rasajna Guttala

    Associate Professor, Department of Pharmaceutical Chemistry, Koringa College Of Pharmacy, Korangi, Andhra Pradesh, India

  • Shaik Munvar

    PG Scholar, Department of Pharmaceutical Chemistry, AU College Of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India

  • Devarapalli Pradeep

    PG Scholar. Department of Pharmaceutical Analysis, Shri Vishnu College Of Pharmacy, Bhimavaram, Andhra Pradesh, India

  • Chaitanya Lahari Meka

    PG Scholar, Department of Pharmacology, Shri Vishnu College Of Pharmacy, Bhimavaram, Andhra Pradesh, India

  • Pamu Divya Sarayu

    PG Scholar, Department of Pharmacology, Shri Vishnu College Of Pharmacy, Bhimavaram,

  • Dr Jami Durga Ganesh

    Director Operations, Sitra Pharmaceuticals Hyderabad, Telangana, India, 

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Published

2024-12-30

Issue

Vol. 27 No. 4S (2024): November Issue

Section

Research Article

License

Copyright (c) 2024 Rasajna Guttala, Shaik Munvar, Devarapalli Pradeep, Chaitanya Lahari Meka, Pamu Divya Sarayu, Dr Jami Durga Ganesh (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

In Silico Docking Studies Of Phyto- Constituents Detected In Nyctanthes Arbor Tristis Flowers Methanolic Extract For Anti Tubercular Activity. (2024). African Journal of Biomedical Research, 27(4S), 18585-18593. https://doi.org/10.53555/AJBR.v27i4S.8790