A New Perspective: Novel Ocular Drug Delivery System

Abstract

Ocular diseases like glaucoma, conjunctivitis, and dry eye syndrome often require frequent medication due to the poor bioavailability of conventional eye drops (<1%) caused by rapid tear turnover. Niosomes, formed by self-clustering nonionic surfactants in aqueous media, improve drug stability, skin penetration, and bioavailability compared to phospholipids. In-situ gels for ocular drug delivery form a gel upon contact with the eye, enhancing adherence, prolonging contact, and enabling controlled drug release.Bromfenac is effective for treating post-surgical inflammation and other eye disorders. This work describes the formulation and evaluation of Niosomal In-situ gel of Bromfenac for ocular delivery. Niosomes were prepared using the thin film hydration technique with of Span 40 and different cholesterol and ratios. The formulations were analyzed in vitro method. And the in-situ gel was prepared using gelling agent Carbopol 934 polymer also acts as permeation enhancer. The developed formulation was characterized for various in vitro evaluation. Developed formulation was clear, isotonic solution, that converted into gel at pH 6.9–7.0. A significant higher drug transport across corneal membrane and increased ocular retention time was observed using the developed formulation F5. The developed system is a possible alternative to conventional eye drops for the treatment of ocular diseases.