Berberine Nanoparticles as a Promising Intervention for Diabetic-Wound Healing: A Comprehensive Review

Abstract

Diabetic-wounds is a very big burden in real time over the health care, as these-wounds take long time to heal and have high probability to get complicacies. Most traditional treatment methods do not provide very effective solutions to manage these wounds. Nevertheless, with the advent of nanotechnology, new alternatives for the design of different therapeutic approaches are now available. Berberine, an alkaloid found in several plant species, acclaimed for a variety of pharmacological applications, has also shown promising role in wound healing. Overview: the following comprehensive review seeks to provide an in-depth insight to the use of Berberine nanoparticles in the treatment of diabetic wounds. This review discusses the groundwork, formulation techniques, and relevant preclinical & clinical researches of Berberine nanoparticles that have shown improved efficiency in wound healing.

This introduction can be a read on diabetic wound pathophysiology and then moves on to the significant therapeutic windows required by new methods. This review seeks to explore the therapeutic potential of Berberine, through wound healing, yet this has not been fully translated for clinical application. Subsequently, the focus will be on nanoparticle-based Berberine delivery systems, detailing the advantages and the formulation strategies of Berberine nanoparticles. The path of Berberine in wound healing, which are anti-inflammatory, anti-oxidant, both pro and anti-angiogenic, and promote the growth of damaged tissue,zwill be discussed. In addition, we summarize preclinical studies demonstrating the efficiency of Berberine nanoparticles both in-vivo and in-vitro. Taken together, this review brings together the current information related to Berberine nanoparticle with diabetic wounding healing, providing a foundation for future work in this emerging field.