A Prospective Observational Analysis Comparing the Safety and Effectiveness of Beta Blockers in Heart Failure with Preserved Ejection Fraction (HFPEF) To Those with Heart Failure with Reduced Ejection Fraction (HFREF)

Authors

  • Dr. sumera iram Author
  • Mohd jawaduddin Author
  • Dinesh kumar Author
  • Prince Tiwari Author

DOI:

https://doi.org/10.53555/AJBR.v28i3S.7332

Keywords:

HFpEF, HFrEF, Bisoprolol, Metoprolol, Carvedilol, Nebivolol.

Abstract

Aim: To compare the effectiveness and safety of beta blockers in heart failure with reduced (HFrEF) and preserved ejection fraction (HFpEF) patients.

Methods: A six-month prospective study at Aware Gleneagles Hospital, Hyderabad, enrolled 100 patients (50 HFpEF, 50 HFrEF). Demographic data, clinical parameters, and medication use were collected and analyzed. Primary endpoints: vital signs, adverse events, and duration of hospital stay. Secondary outcomes: reduction in NT-proBNP, renal impairment, and drug interactions. Statistical analyses: t-tests, chi-square tests, and survival analysis.

Results: Bisoprolol showed maximum efficacy, decreasing NT-proBNP by 22% (HFpEF) and 30% (HFrEF), with lesser side effects and shorter hospitalizations (5.6 ± 1.8 days) compared to Metoprolol, Carvedilol, and Nebivolol.

Conclusion: Bisoprolol is the most efficacious beta blocker for HFpEF and HFrEF patients, enhancing outcomes and reducing side effects.

Author Biographies

  • Dr. sumera iram

    Pharm-D, Sree Dattha institute of pharmacy, 6J5F+H27, Sree Dattha College Rd, Sheriguda, Telangana 501510

  • Mohd jawaduddin

    Sree Dattha institute of pharmacy, 6J5F+H27, Sree Dattha College Rd, Sheriguda, Telangana 501510

  • Dinesh kumar

    Sree Dattha institute of pharmacy, 6J5F+H27, Sree Dattha College Rd, Sheriguda, Telangana 501510

  • Prince Tiwari

    Sree Dattha institute of pharmacy, 6J5F+H27, Sree Dattha College Rd, Sheriguda, Telangana 501510

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Published

2025-04-11

Issue

Vol. 28 No. 3S (2025)

Section

Research Article

License

Copyright (c) 2025 Dr. sumera iram, Mohd jawaduddin, Dinesh kumar, Prince Tiwari (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

A Prospective Observational Analysis Comparing the Safety and Effectiveness of Beta Blockers in Heart Failure with Preserved Ejection Fraction (HFPEF) To Those with Heart Failure with Reduced Ejection Fraction (HFREF). (2025). African Journal of Biomedical Research, 28(3S), 113-120. https://doi.org/10.53555/AJBR.v28i3S.7332