Association of Albumin-to-Creatinine Ratio with Dyslipidemia and Glycemic index in Type 2 Diabetes Mellitus – A cross-sectional study

Abstract

Type 2 diabetes mellitus (T2DM) patients have a high prevalence of dyslipidemia and renal impairment, increasing cardiovascular and renal risk. Albumin-creatinine ratio (ACR) is a marker for early renal impairment, while lipid disorders with elevated LDL-C and triglycerides are common in T2DM. This study aimed to explore the relationship between ACR and lipid profiles. In the retrospective analysis of 300 T2DM patients, ACR showed a weak but significant correlation with total cholesterol (r = 0.117, p = 0.043) and stronger correlations with HbA1c (r = 0.183, p = 0.001) and postprandial glucose (r = 0.154, p = 0.007). Subgroup analysis identified the 41–60 age group as having the highest mean ACR (123.50 mg/g) and triglycerides (147.50 mg/dL). High ACR levels (≥30 mg/g) were linked to low total cholesterol and LDL-C, likely due to lipid-lowering therapies. These findings emphasize integrated monitoring of renal, lipid, and glycemic parameters to mitigate risks of nephropathy and cardiovascular disease.