Formulation And Evaluation Of Niosomal Gels Containing Herbal Plant Extract For Anti-Microbial Activity

Abstract

Niosomes are crucial in drug delivery due to their ability to adjust pharmacokinetics, bioavailability, and reduce toxicity. Applying niosomes to the skin can prolong medication retention in the stratum corneum and epidermis while decreasing drug absorption. Niosomes can also function as reservoirs for drugs, adjusting the release pace and affinity for the target site. Colocasia esculenta Linn, a potential medicinal plant, is known for its flavonoids, β-sitosterol, and steroids. The plant's leaves are rich in vitamin C, while its rootis high in starch and essential nutrients. The juice extract of Colocasia esculenta is used for baldness, stimulant, expectorant, blood pressure relief, and central nervous effects. It also has antioxidant, anti-inflammatory, analgesic, anti-lipid peroxidative, antidiabetic, antihepatotoxic, and antimicrobial effects. In order to improve the low skin penetration and to minimize the side effects associated with topical conventional drug administration, Herbal Extract loaded Niosomes (HEN) were prepared by a thin film hydration method using different ratios of non-ionic surfactants (Soya Lacithin) along with cholesterol (CHO). The formulations were evaluated for size, shape, entrapment efficiency, in vitro drug release, stability assayand anti bacterial study. The results of this study showed that CHO content and the type of surfactant altered the entrapment efficiency and drug release rate from niosomes. Formulation having surfactant and CHO ratio 1:0.2 exhibited higher drug release. From all these studies, it can be concluded that a gel formulation containing Niosomes loaded with Herbal Plant Extract Niosomes showed pro long edaction than formulations Containing Herbal Plant Extract Niosom sinnonｌniosomal form and it can be developed Successfully to improve the microbial activity.