Exploring The Synthesis And Characterization Of Novel Oxazole Derivatives And Its Biological Activity

Abstract

Synthetic chemists now have an appealing platform to introduce structural alteration in the nucleus of 1, 3-oxazole due to its excellent and broad bio-spectrum, which provides easy access to novel methods.  The design and synthesis of a novel series of 1, 3-oxazoles is complete. Excellent yields of the necessary oxazoles are obtained using an effective and straightforward technique. By condensing acetanilide with amides in the presence of bromine as a catalyst, a unique sequence of five oxazole derivatives were produced. The compounds are designated as 2-methyl-N-phenyl oxazole-4-amine, N-2-diphenyl oxazole-4-amine, N-phenyl oxazole-4-amine, 2-ethyl-N-phenyloxazol-4-amine, and N4-phenyl oxazole- 2, 4-diamine. Additionally, the compounds' promising biological activity were tested for. 1, 3-Oxazoles are widely used as pharmacophore and have a broad range of biological properties in medicinal chemistry.

DDPH scavenging activity and hydrogen peroxide activity were used to examine the in-vitro antioxidant properties of every synthesised molecule. To determine the percentage of inhibition of each compound, the compounds were evaluated at various concentrations ranging from 0.02-0.10 mg/ml. In contrast to regular acarbose, compound A3 had significantly substantial action against hydrogen peroxide and DPPH.

A pilot study was conducted to investigate the antimicrobial activity. Two bacterial strains and one fungus strain were tested for antibacterial and antifungal properties, respectively. Comparing compounds A3 and A4 to standard medications (ciprofloxacin for antibacterial activity and itraconazole for antifungal activity), the results demonstrated that they had strong antibacterial and antifungal activity. The other compounds evaluated had moderate to good efficacy under these conditions.