Comparative In Vivo And Clinical Study Of Karamardadi Tablet And Diclofenac Sodium Tablet In Post Haemorrhoidectomy Pain Management In Wister albino Rats

Abstract

Background: Karamard ( Carissa carandas) is species of flowering shrub with Apocynaceae family with black sweet or sour fruits abundant in high temperature regions rich in Iron, vitamin C, Calcium and Vitamin A. Its fruits are used in Ayurveda to treat acidity, skin rashes, fever. ¹The present herbal compound i.e. KARMARDADI YOGA is in practice for analgesia which relieves pain , which could be used to supplement anesthesia as well as get rid of adverse effect of modern analgesic drug.

Objectives: The present investigation in Wistar Albino Rat is to evaluate the Preclinical safety of Karamardadi tablet.

And also  investigate an analgesic effect of Karamardadi tablet in wister albino rats.

Materials and methods:For acute toxicity study  one group consisting 03 animals (2 groups). The test item has been administered orally at a dose of 2000mg/kg on day one of the experiment.

For analgesic effect, Male albino wistar rats 150-200gare divided into five groups, each group consisting of six rats.

A tail flick analgesia meter is used for this test.

Results: It is observed that oral administration higher doses of karmardadi tablet for 21 days  led to a notable elevation in the pain threshold, demonstrating a significant increase comparable to that achieved with Diclofenac sodium. This suggests promising potential for the extracts as potent analgesics.

Conclusion: There was no mortality observed in rat after administration of test items once at a dose of 2000mg/kg.

It could be deducted from results obtained from this study that karmardadi tablet have analgesic property in albino rats, yet emphasized the necessity for clinical trials.