The Prevalence Of Insulin Resistance In Non-Diabetic And Diabetic Patients With Chronic Kidney Disease

Abstract

Objectives: Chronic kidney disease (CKD) is characterized by kidney damage lasting longer than three months and reduced kidney function according to the measured glomerular filtration rate (eGFR). The two main causes of CKD are diabetes mellitus and hypertension; however, insulin resistance (IR) is identified as a possible risk factor in CKD patients that can lead to an independent predictor of cardiovascular death. The study describes the prevalence of insulin resistance in diabetic and non-diabetic patients with CKD

Materials and Methods:  A cross-sectional study was conducted on 88 CKD individuals among them 44 diabetic and 44 non-diabetics recruited from SRIHER for the period of 6 months. The association between IR and HOMA-IR was assessed using ELISA and the biochemical parameters of FBS, RFT and HbA1c.  

Statistical analysis:  The statistical analysis was done using SPSS version 23.0. Group variables are compared and presented as mean±SD using one-way ANOVA analysis of variance. Pearson’s correlation was done among groups and significant levels is (p<0.05*).

Results: It showed a significant difference in insulin resistance between diabetic and non-diabetic groups. In diabetic patients, HbA1c and FBS levels were found significant whereas in non-diabetic levels of creatinine and fasting insulin increased compared to diabetic. A correlation analysis on insulin shows a significant difference among diabetic and non-diabetic CKD (p<0.00**).

Conclusion: Study shows significant increase in IR in non-diabetic compared to diabetic group. It also showed a positive correlation between insulin, glucose, HOMA-IR, and creatinine. This indicates high risk of developing diabetes in nondiabetic CKD patients.