Platelet-Rich Plasma (PRP) Ovarian and Endometrial Infusion in Improving ART Outcomes

Abstract

Assisted reproductive technology (ART) has transformed infertility treatment, yet challenges persist, particularly among patients with diminished ovarian reserve and recurrent implantation failure. Recent advancements have introduced autologous platelet-rich plasma (PRP) infusions into ovarian and endometrial tissues as potential interventions to enhance ART outcomes. This mini-review examines the mechanisms by which PRP may improve oocyte quality and implantation rates, supported by both existing literature and preliminary data from our center, where over 150 patients have benefited from PRP treatments, resulting in improved oocyte quality, enhanced implantation rates, and successful ongoing pregnancies. The review also discusses the safety profile of PRP infusions and identifies areas requiring further research to establish standardized protocols and long-term efficacy.