Synthesis And Characterization Of Nanocomposite Hydrogel Scaffolds Based On Chitosan/Sodium Alginate Containing Halloysite Nanotubes With Biomedical Applications

Abstract

This study aimed to develop hybrid hydrogel beads as biocompatible scaffolds using chitosan (CS) and sodium alginate (Alg), incorporating varying concentrations of halloysite nanotubes (Hal) (3, 6, and 9% w/w) and cross-linked with Ca²⁺ ions. The synthesized hydrogels were thoroughly characterized using various analytical techniques, including FTIR, XRD, SEM/EDX, and TEM. The varying Hal concentrations significantly influenced the properties of the hydrogels, as evidenced by swelling behavior analysis, which revealed a decrease in swelling capacity with an increase in Hal content. The water uptake capacity was decreased along with an increase in the percentage of Hal in hydrogels. All hydrogels revealed a substantial water content exceeding 80%. The addition of Hal had a non-significant effect on the water retention abilities of the hydrogels. The hemolysis test showed good hemostatic properties of the hydrogels. Therefore, hydrogels showed hopeful application properties in biomedical applications.