Exploring Efficient Synthetic Routes to Flavanones from Substituted O-Hydroxychalcones And O-Benzoyloxyacetophenones

Abstract

The synthesis of flavanones is a significant area of research due to their diverse biological activities and potential pharmaceutical applications. This study focuses on the synthesis of flavanones using substituted o-hydroxychalcones and substituted o-benzoyloxyacetophenones as starting materials. Both pathways offer efficient and selective routes to flavanone derivatives. In the first approach, substituted o-hydroxychalcones undergo cyclization under acidic or basic conditions to yield the desired flavanones. The presence of electron-donating or electron-withdrawing substituents on the aromatic rings influences the reaction rate and yield. The second pathway involves the synthesis of substituted                   o-benzoyloxyacetophenones, which then undergo acid catalysed cyclization to form flavanones. This method provides an alternative route that can accommodate a wide range of substituents, potentially enhancing the versatility of the synthetic process. Comparative analysis of these methods reveals differences in reaction conditions, yields, and substrate scope, highlighting the importance of choosing the appropriate starting material based on the desired flavanone derivative. The resulting flavanone derivatives exhibits varied pharmacological properties, underscoring the potential of these synthetic routes in drug discovery and development. This study contributes to the field by offering optimized protocols for flavanone synthesis, facilitating the exploration of their therapeutic potential.