"To Study the Relationship of Hypertension with Insulin Resistance"

Abstract

Hypertension is a significant global health challenge and a major risk factor for cardiovascular diseases and metabolic disorders. Insulin resistance, often associated with hypertension, plays a pivotal role in the development of metabolic syndrome and type 2 diabetes. This study aims to explore the relationship between hypertension and insulin resistance, focusing on the correlation between insulin resistance and varying grades of hypertension. A cross-sectional observational study was conducted on 190 participants, comprising 95 hypertensive and 95 non-hypertensive individuals. Key parameters such as blood pressure, fasting glucose, fasting insulin, lipid profiles, and the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) were evaluated.
The results revealed a statistically significant association between hypertension and higher levels of insulin resistance (p < 0.001). Additionally, patients with Stage II hypertension exhibited significantly higher HOMA-IR values compared to those with Stage I hypertension. The findings underscore the bidirectional relationship between hypertension and insulin resistance, highlighting the need for integrated clinical management to mitigate cardiovascular and metabolic risks. Future studies should focus on the mechanistic pathways and the impact of targeted interventions.