Factors Affecting The Response To Anti Vegf Injection In Patients With Diabetic Macular Edema On Optical Coherence Tomography

Abstract

Aim: To evaluate outcomes in patients with Diabetic Macular Edema (DME) and its association among HD-OCT features, blood investigations, Visual and Anatomical undergoing treatment with Intravitreal Bevacizumab Anti VEGF Injection.

Method: A hospital-based Non-Randomised Interventional Study was conducted for a six months duration. All patients diagnosed of having DME, who came to the Department of Ophthalmology, at Acharya Vinobha Bhave Rural Hospital and underwent Intravitreal Anti VEGF Bevacizumab Injection therapy were incorporated in the study. An in-depth and detailed ophthalmic examination was done for each patient along with OCT.

Result: The occurrence of DME was found to the highest in the age group of 50-59 (44.4%). On univariate analysis, the association of HbA1c levels between 6-9% at the time of Intravitreal injection showed better visual outcome on 4 weeks follow up. Of the 36 patients, 6 (16%) patients had a vision of > 6/18. Macular Edema showed a mean value of 374.88µm. There was moderate correlation between macular thickness and visual outcome of patients. The intravitreal treatment and the systemic parameters investigated in this study did appear to be correlated with the BCVA.

Conclusion: OCT is an imaging modality that is extensively used in routine retina practice to obtain a high-definition cross sectional view of all retinal layers and to measure its thickness. Administration of  in individuals with controlled sugar levels has proven to yield better visual outcome and a moderate reduction in the macular thickness. A correlation of these factors with timely care and management can result in lesser factors affecting the outcome of Intravitreal Injections.