A Prospective Comparative Study Of Surgical Site Infection After Single Dose Of Preoperative Antimicrobial Prophylaxis Versus Multiple Dose Of Antimicrobials In Clean Abdominal Surgeries

Abstract

Surgical Site Infections (SSI) has always been a major complication of surgery. Most SSIs are caused by contamination of an incision with microorganisms found from patient’s own body during surgery. Abdominal surgeries have high chance of developing SSI. There is good evidence that systemic antibiotic prophylaxis reduces wound infection rates. However, studies are required to prove the efficacy and safety of single dose regimen over multiple dose regimens.

The main objective of the study was to investigate the efficacy and safety of single dose of antimicrobial against routine multiple doses of antimicrobials in clean abdominal surgeries with cost effectiveness between the two groups (Group A and Group B) and also to study the rate of surgical site infections between the two groups in a tertiary care hospital. The study was evaluated by injecting single dose of Taxim (cefotaxime sodium 2 gm) intravenously 30 minutes before induction of anesthesia versus multiple doses of injection Taxim carried over postoperatively and to study the rate of local wound infection in cases. Southamptom wound grading system was used to assess the Postoperative wound. In the present study both the groups had similar outcome. Hence, single dose regimen can be considered as a cost effective modality in clean abdominal surgeries.