Synthesis, Characterization And Anticonvulsant Activity Of Sustituted Imidazolinone Derivatives

Abstract

The reaction of glycine with benzoylchloride gave 2-benzamidoacetic acid (1) which on reaction with substituted benzaldehydes in presence of acetic anhydride and anhydrous sodium acetate gave 4-benzylidene-2-phenyloxazol-5(4H)-one derivative (2a-h).  The 2, 4-di nitro chlorobenzene on reaction with hydrazine hydrate gave 2, 4-dinitrophenylhydrazine (II) which on reaction with 4-benzylidene-2-phyenyloxazol-5(4H)-one (2a-h) in presence of pyridine yielded the final series of (Z)-4-benzylidene-1-((2,4-dinitrophenyl)amino)-2-phenyl-1H-imidazol-5(4H)-one (3a-h) respectively.  All newly synthesized compounds were characterized on the basis of IR, ¹H NMR and Mass spectral data and screened for their anticonvulsant activity.