Relationship between Vitamin B12 levels and Metformin usage in patients with Type 2 Diabetes Mellitus.2 Diabetes Mellitus

Abstract

Diabetes Mellitus is a chronic, metabolic disease characterized by increased blood glucose levels, which leads to damage to the heart, vasculature, eyes, kidneys and nerves.Over 90% of diabetes mellitus cases were found to be type 2 diabetes mellitus.Vitamin B12 have a role in the etiology of glucose intolerance, and as glucose tolerance worsens, vitamin B12 levels typically fall.² Metformin is the most commonly used treatment to increase insulin sensitivity in insulin resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and obesity. Several researchers have made recommendations to screen for serum B12 levels in type 2 diabetes mellitus patients treated with metformin .In our study we estimated serum Vitamin B12 levels in Type2 diabetes mellitus patients taking metformin and compared the serum Vitamin B12 levels in diabetic patients at different age groups includes140 diabetic patients.The Normal serum Vitamin B12 concentration was found to be 14.3% in both male and females with age less than 60 years of age and 10.7% in age group more than 60 years of age. High Serum Vitamin B12 concentration was found to be 42.1% in both male and females with age group less than 60 years of age and 32.9% in age group more than 60 years of age.One way ANOVA WAY Statistical Analysis was done for Serum Vit B12 levels in patients with age less than 60 years and shown in table 5.The f-ratio value is 20.20024. The p-value is < .00001. The result is significant at p < .05. One way ANOVA WAY Statistical Analysis was done for Serum Vit B12 levels in patients with age more than 60 years . The f-ratio value is 13.08544. The p-value is < .00001. The result is significant at    p < .05.The novelty of our study recognized an elevated serum Vitamin b12 levels in diabetic patients may be an indicator of glycemic variability and wider fluctuation in blood glucose level.So monitoring these parameters in diabetic patients may help in predicting and preventing the complications of Diabetes Mellitus.