Recent Advances In The Treatment Of Psoriasis With The Inclusion Of In Situ Gels: A Review

Abstract

Sought in this manner, psoriasis is an old-standing skin condition that is precipitated by immune system of the bodies attacking skin cells and causing them to reproduce more than required, leading to formations of scales on skin surface. However, traditional medications can encounter some issues leading to poor patients’ compliance and appearance of side effects topping at the body systems. The above challenges have been well managed through in – situ gelling systems which is used in a sustained and localized drug delivery near or at the site of affected tissue through the topical route. The discussions of in-situ gel formation, mechanism of action, polymers and excipients, and choice of drugs in formulating treatment for psoriasis will be made in this review. Concerning the understanding of effectiveness of in-situ gels for the purpose of improving the therapeutic values, it is possible to explain the effectiveness through use of techniques such as gelation temperature, drug release profiles skin permeation and stability assessments. In addition, the review claims the advantages and disadvantages of the in-situ gel systems and offers the information for the further study of the approach to the treatment of psoriasis. In conclusion, In-Situ gels provide motivation for the delivery of the anti-psoriatic agents, enhances patient compliance and reduces the side effects hence making In-situ gels a useful tool in servicing Psoriasis patients.