Comparison Study Between Moringa Oleifera And Green Tea Aqueous Extracts As Anti-Obesity In Experimental Animals

Abstract

Background: Obesity is considered one of the major risk factors for several chronic diseases, especially liver, kidneys, and pancreas. Moringa (Moringa Olifera L.) is a highly valued plant distributed in various countries; it has an impressive range of folk medical uses, including anti-inflammatory, wound-healing, diuretic, and antioxidant high nutritional value. In addition, green tea (Camellia Sinesis L.)  has recently attracted significant attention considering one of the most popular beverages consumed worldwide, possessing various benefits including antioxidants, anti-inflammatory and weight management, Study aim: This investigation aimed to compare the anti-obesity activity of moringa oleifera and green tea aqueous extracts in experimental animals.  Materials and methods: Three aqueous extracts of green tea, moringa, and a mixture were prepared using 5 g each added to 100 mL of boiling water (5% w/v). Thirty male albino rats weighing 200±5 g were divided into five groups (n=6 rats) as follows: Group (I) was considered as negative control which fed on basal diet all over the experiment period, group (II) considered as positive control group which fed on a high-fat diet all over the experiment period, group (III) considered as obese rats which was fed on a high-fat diet for 28 days, then, orally administered 5% moringa aqueous extract for 28 days, group (IV) considered as obese rats which was fed on a high-fat diet for 28 days, then, orally administered 5% green tea aqueous extract for 28 days, finally, group (V) considered as obese rats which was fed on a high-fat diet for 28 days then orally administered with 5% mixture of moringa and green tea aqueous extract for 28 days. Bodyweight and feed intake were measured during the experimental period, and the feeding efficiency ratio was calculated. At the end of the experiment, all rats were mercy sacrificed; blood samples were collected to determine lipids profiles, liver enzymes, and kidney functions, moreover, organs were weighed to calculate weight percentage, and histopathological changes were measured. Results: The result revealed that oral administration of 5% aqueous extracts of moringa, green tea, and a mixture of them induced a significant reduction in body weight in obese rats and promoted lipid profiles, liver enzymes, kidneys functions, and histopathological results for all tested groups revealing that the mixture revealed the best treatment. Conclusion: This investigation concluded that moringa, green tea, and their mixture aqueous extracts at a dose of 5% could be used for weight reduction and enhancing lipid profiles, liver enzymes, and kidney functions with histopathological improvement in obese rats with less or no side effects. Moreover, moringa possesses a greater effect as a weight loss supplement than green tea.