Formulation And Optimization Of Fusidic Acid And Diclofenac-Loaded Microsponge Gel For Effective Topical Drug Delivery
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Keywords

Microsponge Delivery Systems (MDS)
Box-Behnken design
Fusidic Acid
Diclofenac
Particle Size
Zeta Potential etc

Abstract

Microsponge Delivery Systems (MDS) represent an innovative strategy for achieving controlled drug release while minimizing adverse effects. This research focused on developing and optimizing a gel formulation containing Fusidic acid and Diclofenac microsponges applying the quasi-emulsion solvent diffusion technique. Ethyl cellulose was utilized as the polymer, with triethyl citrate acting as the plasticizer, and polyvinyl alcohol as the surfactant. The microsponges were evaluated based on parameters like particle size, zeta potential, drug entrapment efficiency, and morphology. Through Box-Behnken design optimization, the ideal formulation (MPF 11) was identified, featuring a particle size of 287.1 nm, an entrapment efficiency of 89.6%, and a zeta potential of -16.8 mV. These microsponges were subsequently incorporated into a gel intended for topical use. In vitro release studies revealed a controlled release pattern, and the gel exhibited favorable physical characteristics. Stability testing confirmed the formulation’s efficacy under accelerated conditions. The findings underscore MDS as a promising platform for enhancing topical drug delivery.

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