Anti-Inflammatory Activity Of Conus Toxin From Conus Kintoki

Abstract

Rats with swollen paws from carrageenan were used to check if Conus kintoki venom has anti-inflammatory effects. The goal of this study was to find out if C. Kintoki venom can be a helpful alternative to regular pain relievers like ibuprofen. Paw thickness, which shows how much swelling there is, was checked at different times after getting different amounts of C. kintoki venom (5 mg/kg and 15 mg/kg) was tested, and the results were compared to a group that got ibuprofen and another group that had inflammation caused by carrageenan. The working parts of C. Kintoki venom, which contains substances called conotoxins, is famous for its strong ability to target specific parts of the nervous system, like ion channels, receptors, and transporters. Unlike traditional NSAIDs, which often cause stomach and heart problems, this new way of working might be safer. The study highlights that conotoxins could be used as new anti-inflammatory medicines. We need to do more research to find out which conotoxins cause the anti-inflammatory effects and to understand how they work. Understanding these relationships could lead to new and better anti-inflammatory medicines that are safer to use. In short, the poison of C. Kintoki has good anti-inflammatory properties, which means it might be a useful alternative to regular pain relievers like NSAIDs. This work opens the door for future studies on marine poisons and how they can be used to make anti-inflammatory medicines.