A Study To Compare Health Status High-Sensitivity C-Reactive Protein And Lipid Profile In Patients With Adult-Onset Type2 Diabetes Mellitus

Abstract

The most significant and challenging health issue of the modern era is diabetes mellitus and its complications. Inflammation plays a crucial role in the development and progression of diabetes. Type 2 Diabetes Mellitus patients (T2DM) are at significant risk of developing cardiovascular diseases. High-sensitive CRP (hsCRP) has become a reliable indicator of low-grade inflammation. Since very little is known regarding the relationship between hs-CRP and T2DM, the goal of this study was to evaluate hs-CRP levels and lipid profile and to study their relationship to cardiovascular problems in Type 2 Diabetes Mellitus patients.

Material and Methods:

The current study was carried out at Rajeev gandhi College and Hospital in Bhopal. The study group consisted of 60 healthy controls and 60 Type 2 Diabetes Mellitus patients who had been diagnosed following WHO criteria. Serum hs-CRP concentrations as well as the lipid profile (total cholesterol, HDL, and TG) were assessed. Descriptive Statistics Calculator(https://www.calculatorsoup.com/calculators/statistics/descriptivestatistics.php) and https://  www. so csci statistics.com/tests/studentttest/default2.aspx was used to analyze the data.

Results:

In comparison to controls, individuals with Type 2 Diabetes Mellitus had significantly higher levels of hsCRP, with a mean value of 2.74 +1.20 (p 3 mg/L, with a high risk of developing CVD whereas 32 (53%) of them had an intermediate risk of developing CVD with serum hs-CRP values between 1-3 mg/L. Conclusion: The present study showed that patients with T2DM had considerably higher levels of hs-CRP and lipid parameters than the controls. Furthermore, it was indicated that in patients T2DM patients with higher hs-CRP levels >3 mg/L there was a significant association between BMI, serum LDL-C, total cholesterol, and triglycerides. These results imply that hs- CRP may serve as a helpful tool for assessing atherosclerosis risk and cardiovascular complications in T2DM  patients.