Correlation Between Lipid Profile Biomarkers and Pre- and Postmenopausal Breast Cancer Patients in Iraqi Women.

Abstract

The current study aims to evaluate the relationship between Iraqi women subjected to breast cancer (BC) and their serum levels of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C). The study was conducted on one hundred women's, sixty women's with BC and fourty women healthy. The samples were divided in to two groups (pre-menopausal and post-menopausal). Concentration of serum TC, TG, HDL-C were determined by enzymatic colorimetric method using Semi-Auto Analyzer instrument (spectrophotometry) and serum level of LDL-C and VLDL-C was estimated by Friedewald's equation. All the biochemical values showed significant differences between the BC patients and healthy controls. The obtained results showed that the concentrations of HDL-C in pre-menopausal and post-menopausal BC were substantially lower than the healthy groups (P≤0.05), while the concentrations of serum TC, TG, LDL-C and VLDL-C levels was significantly higher than the healthy groups (P≤0.05). In addition, BMI (Body Mass Index) in pre and post-menopausal was statistically associated with high lipid profile level. Based on these findings, it can be concluded that lipid profile can be considered as risk factors for women's with BC. Therefore, routine screening of these parameters in women's with BC is recommended to reduce the incidence of disease.