Systematic physicochemical characterization of potent anticancer drug paclitaxel loaded solid lipid nanoparticles with herbal adjuvants

Abstract

The purpose of the study was to develop and analyze a solid lipid nanoparticle (SLN)- based Paclitaxel drug delivery system. The SLN's lipid & surfactant components were oleic acid & soy lecithin (Tween 80). Numerous batches of paclitaxel-containing solid lipid nanoparticles were produced using size-reduction methods, solvent emulsification by ultrasonication, and different drug and lipid doses. Excipients were employed in tests where the formulation characteristics were improved by varying the ratios of medicines, lipids, and surfactants. The created formulations underwent assessments in the areas of drug content, in-vitro drug release, particle size analysis, scanning electron microscopy, Fourier transform-infrared studies, differential scanning calorimetry, and stability. Additionally, it was discovered that the improved formulation performed well with each of the formulation's constituents as demonstrated by FTIR and DSC data. The solid lipid nanoparticles that were created have a size of 200.01 nm. After three months at 5±3∘ C and 25± 2∘ C/60± 5% RH, the improved formulation showed no significant modifications in appearance, drug content (%), drug entrapment efficiency (%), or in vitro drug release (%)