Histopathological and Biochemical Changes of Cyproheptadine hydrochloride effect on liver and kidney in albino mice

Abstract

The current study aimed to identify some of the effects resulting from the administration of Cyproheptadine hydrochloride to mice by subcutaneous injection at concentrations of 25 and 50 μg/kg for 21 days. Three groups of six mice each were formed out of the animals. The medicine was administered to the second and third groups at concentrations of 25 and 50 μg/kg, respectively, with the first group acting as the control group. Their weights were regularly recorded to measure the drug's impact on their weights, the results showed a substantial difference between the groups (P<0.05). Moreover, the concentrations of liver function tests (ALT and AST) were measured and compared to the control group. While changes in the renal function tests (urea and creatinine) revealed a substantial increase in creatinine and a non-significant increase in urea, the observed data showed a significant increase in ALT and AST.