Copper(II), Cobalt(II), Nickel(II) And Zinc(II) Complexes Obtained From Chelidamic Acid And Morpholine: Synthesis, Characterization, Biological Evaluation And In Silico Studies

Abstract

In the modern pharmacological landscape, the focus has shifted from small organic compounds to the synthesis of transition metal complexes, which are essential. To this connection, the present work describes chelidamic acid-based first-row transition metal complexes that were synthesised and characterized completely. In-vitro anti-diabetic, total anti-oxidant and anti-inflammatory activity of the metal complexes were studied with standard drug molecules. Molecular docking studies have explained the results of these investigations, while DFT studies have analysed the reactivity of the metal complexes. Molecular electrostatic potential was also investigated to the extent of DFT, and the activity of the metal complex was justified by combining the findings of both theoretical and experimental investigations.