Anticariogenic Activity Of Pterocarpus Santalinus Ethanolic Extract Against Oral Pathogens - An In Vitro Study

Abstract

Background and aim:

Plants are used for various purposes in our day to day life. Plants are a valuable source of bioactive compounds and it is used for medicinal purposes all over the world. Recently, many drugs are being synthesised from medicinal plants and they are used to treat various diseases including cancers. The aim of the present study is to study the anticariogenic activity of pterocarpus santalinus ethanolic extract against oral pathogens.

Materials and methods:

Five grams of dry powder of pterocarpus santalinus were weighed and taken. 50 ml of ethanol were used and ethanolic extract was prepared  and kept in an orbital shaker ( RPM - 73) for 24 hours . On the next day the mixture was kept on a magnetic stirrer at the RPM - 0230. Then the extract was filtered using Whatman filter paper no.1 on a buchner funnel. Then the filtered mixture was boiled at 50°C for 20 minutes.The obtained data were analysed statistically by Spearman  correlation analysis(r=1). Non parametric correlation was significant at p value less than 0.05. The correlation analysis was done to analyse the anticariogenic activity of pterocarpus santalinus ethanolic extract.

Results:

Candidiasis albicans showed a maximum  zone of inhibition (p<0.05) 33mm in 150µL for anticariogenic property. The correlation analysis was done to analyse the anticariogenic activity of pterocarpus santalinus ethanolic extract.Based on the results recorded in the present study, it is concluded that pterocarpus santalinus has a potential anticariogenic activity on human oral pathogenic microorganisms.

Conclusion:

Based on the results it is concluded that pterocarpus santalinus has a potential anticariogenic activity on human oral pathogenic microorganisms. Hence the present study  findings provide a wonderful  scientific base for some of the medicinal claims of Pterocarpus santalinus.