Formulation & Evaluation Of Sustain Release Tablet Of Captopril Using Natural Polymers

Abstract

Captopril, an angiotensin-converting enzyme (ACE) inhibitor, is widely used to manage hypertension and congestive heart failure. Despite its therapeutic benefits, Captopril's short half-life necessitates frequent dosing, which can affect patient compliance. To address this, sustained-release (SR) formulations are developed to extend the drug’s effect, reduce dosing frequency, and maintain stable plasma levels (Shah et al., 2019).