A Study Of Bacteriological Profile And Antibiotic Sensitivity Pattern Of Diabetic Foot Ulcer Patients In A Tertiary Care Hospital Of West Bengal

Abstract

INTRODUCTION- Diabetic foot ulcer(DFU) is a dreaded complication among diabetic patients for which peripheral neuropathy and impaired micro vascular circulation are predisposing factors. Multiple hospitalization and increased exposure to antibiotics often lead to multidrug resistant infections, thus increasing the morbidity associated with the condition as well as making it difficult for the clinician to treat it ultimately leading to amputation of the affected foot.

AIM OF THE STUDY -

1. To determine the bacteriological profile of  organisms isolated and the socio-demographical profile of diabetic foot ulcer patients.
2. To assess the antibiotic susceptibility pattern of the different bacterial pathogens isolated from diabetic foot ulcer  

MATERIALS AND METHODS- Isolation and identification of different bacteria from aseptically collected clinical samples of patients with DFU were done by standard microbiological procedures. Antibiotic susceptibility testing was done by Kirby-Bauer’s disc diffusion method on Muller-Hinton agar and results interpreted according to CLSI guidelines 2024..

RESULTS- Staphylococcus aureus was found to be  the predominant bacteria  isolated  from the DFU patients in our study.. Males  were affected  more than female patients and the predominant age group affected was 61-80 years There was higher cases in rural population as compared to urban.. GPC like Staphylococcus aureus were mostly sensitive to Vancomycin and Linezolid, Gram negative pathogens showed good sensitivity to Carbapenems ,Piperacillin-Tazobactam and Cefoperazone-Sulbactam.

CONCLUSION- Increasing prevalence of drug resistant pathogens in diabetic foot ulcers is a major cause of concern which has severely increased the morbidity in such patients nowadays.. Knowledge of sensitivity and resistance patterns of the antibiotics to the isolated bacteria  will help clinicians  with correct empirical treatment and to prescribe the best  antimicrobials thus reducing morbidity and mortality from this grave clinical condition.