A Study Of Thyroid Profile And Lipid Profile Abnormalities In Chronic Kidney Disease Patients In A Tertiary Health Care Centre In Chengalpattu District, Tamil Nadu.

Abstract

Background:

Chronic kidney disease (CKD) is an alarming health problem all over the world.  People with impaired renal function is increasing day by day. Progression of CKD is related to number of associated  complications such as thyroid dysfunction, dyslipidemia and cardiovascular diseases. The following study was conducted to assess thyroid and lipid profile abnormalities in CKD patients and its progression.

Methods:

A retrospective cross sectional study was conducted among 137 chronic kidney disease patients by collecting data from Karpaga vinayaga institute of medical sciences and research center (KIMS&RC), chengalpattu. Serum urea, serum creatinine, triiodothyronine (T3),  thyroxine (T4), thyroid stimulating hormone (TSH), total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and triglyceride values were collected from case sheet records of KIMS&RC and study was conducted and data were analysed.

Results:  in our study, 137 CKD patients are studied in which there are 64 (37%) females and 73 (43%) males. Among 137 patients, 116 patients (84%) may be smoking or alcoholic history. 93 (67%) patients have hypertension and 79 patients (57%) have diabetes.  Stages of CKD are determined by egfr values. egfr values was calculated using serum creatinine value by 2021 CKD-EPI equation. As stages of CKD progresses, triglycerides, LDL, total cholesterol, VLDL and HDL are increasing. LDL, total cholesterol, HDL, VLDL, Triglyceride values are statistically significant as CKD stages progresses from stage 2 to 4. Triglyceride, HDL, LDL, Total cholesterol, VLDL are statistically significant with  p value 0.002, <0.001, <0.001, <0.001 and <0.007 respectively. But TSH and T3 is not much significant according to our study data as CKD stage progresses from stage 2 to 4 with p value 0.05 and 0.199 respectively

Conclusions:  In our study, thyroid profile in CKD patients have not much significance. But lipid abnormalities as CKD progresses from stage 2 to 4 are statistically significant which indicates that total cholesterol, triglyceride, LDL, VLDL and other lipid parameters are elevated in CKD patient as CKD worsens.