The Study Of Association Of Serum Bilirubin Levels With Diabetic Retinopathy And It’s Correlation With Hba1c

Abstract

Objective:

To study the association of total serum bilirubin concentration in patients of type 2 DM with and without diabetic retinopathy and its correlation with the HbA1c levels

Methods:

A total of 200 cases were studied. Patients were divided into two groups: Cases (Diabetes Mellitus with Diabetic Retinopathy), and Controls: (Diabetes Mellitus with no evidence of Diabetic Retinopathy). Three milliliters of venous blood were drawn from the patient on the day of examination and serum total, direct, indirect bilirubin level, was measured by Modified Malloy – Evelyn method. The data for Haemoglobin A1c (HbA1c) values, which was done in our biochemistry laboratory was also collected and evaluated.

Results:

An inverse correlation of HbA1c levels with S. bilirubin levels was observed in both the groups. Mean serum bilirubin levels in non-proliferative type of diabetic retinopathy were found to be significantly higher (0.64#0.32 mg/dl) as compared to that of proliferative type (0.39#0.18 mg/dl) (p=0.003) of diabetic retinopathy.

Conclusion:

A significant gradual decline in mean Serum bilirubin levels was observed with onset of diabetic retinopathy and its progression from mild to severe grades of non-proliferative to proliferative retinopathy (p<0.001). S. bilirubin levels showed a significant mild inverse correlation with HbA1c levels in overall as well as both the groups independently.