Plasma Uric Acid Levels And Renal Function In Type 2 Diabetes Mellitus

Authors

  • Dr. Sumina Cherian Author
  • Dr. Lokesh Mustoor Raman Author
  • Dr. Shivakumar Pujari Author
  • Dr.Prashanthkumar Goudappala Author

DOI:

https://doi.org/10.53555/AJBR.v27i3.1455

Keywords:

Type 2 Diabetes Mellitus (T2DM), plasma uric acid, renal function, estimated glomerular filtration rate (eGFR), diabetic nephropathy

Abstract

Objective: This study investigates the correlation between plasma uric acid levels and renal function in Type 2 Diabetes Mellitus (T2DM) patients. Elevated uric acid levels have been associated with diabetic complications, particularly renal damage.

Methods: A total of 160 participants, including 80 T2DM (Group D) patients and 80 normal controls (Group N), were examined. Plasma levels of glucose, creatinine, urea, electrolytes, and uric acid were measured. Renal function was assessed using estimated glomerular filtration rate (eGFR). The study categorized T2DM patients based on sex, age, and eGFR stages.

Results: T2DM patients exhibited significantly higher plasma uric acid levels compared to controls (p<0.001). eGFR found to be significantly lesser in T2DM patients compared to controls (P<0.05). Gender-based comparisons revealed lesser eGFR levels in females.

Conclusion: Plasma uric acid levels are elevated in T2DM patients. Uric acid may serve as a marker for renal damage in T2DM, highlighting its role in diabetic nephropathy progression.

Author Biographies

  • Dr. Sumina Cherian

    Associate professor, Dept. of Biochemistry, Sree mookambika institute of medical sciences,kulasekharam, Kanyakumari - 629161, Tamilnadu,

  • Dr. Lokesh Mustoor Raman

    Professor, Department of General Medicine, Sri Siddhartha medical college, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka - 572107,

  • Dr. Shivakumar Pujari

    Professor and Head, Department of Biochemistry, Sri Siddhartha medical college, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka- 572107,

  • Dr.Prashanthkumar Goudappala

    Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, Karnataka, India, 

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Published

2024-09-17

Issue

Vol. 27 No. 3 (2024): September Issue

Section

Research Article

License

Copyright (c) 2024 African Journal of Biomedical Research

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Plasma Uric Acid Levels And Renal Function In Type 2 Diabetes Mellitus. (2024). African Journal of Biomedical Research, 27(3), 257-262. https://doi.org/10.53555/AJBR.v27i3.1455