Smoked Food Consumption as Significant Risk Factor for Advanced Breast Cancer on Bone Scan in Southwest Nigerian Hospital

Abstract

The ingestion of smoked foods has been linked to the development of cancer. Polycyclic aromatic hydrocarbons have been 
recognized as carcinogenic compounds which contaminate smoked foods; their ingestion has been linked to the development of 
cancers such as breast cancer. Breast cancer may be evaluated using the nuclear bone scan as an imaging modality. This study 
reviewed bone scan results of patients with a positive history of consumption of smoked foods who presented at a Nuclear 
Medicine facility in South-West Nigeria. Our results show a significant association between a positive history of consumption 
of smoked foods and the presence of advanced breast cancer on the bone scan ((χ2 = 11.190, p = 0.001, df = 2; Crude Odds Ratio 
(95% CI) = 1.692 (1.242-2.304). Thus, those patients with a history of eating smoked foods have between 50-100% increase in 
the risk of having abnormal scan findings. In a logistic regression, this association was retained (AOR=0.591 (0.434-0.805). 
Recommendations are made to address the significance of these findings